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Professor Dong Won Lee Develops Anti-Inflammatory Nanoparticles 

국제교류부 (hqiof) 2012/01/25 17:42:20

이동원 교수, 신개념 고분자 개발 학계 주목

Department of BIN Fusion Technology Professor Dong Won Lee is receiving considerable praise in the academic community for his contribution to developing a new medical application for nanoparticles. The research pertaining to this discovery has been submitted to Biomaterials, one of the leading journals in the field of biomaterials science. The research and its ensuing implications were also briefly explained in the Controlled Release Society’s monthly Newsletter under the title of “Anti-inflammatory and Antioxidant Polyoxalate Nanoparticles for Drug Delivery Applications.”


Prof. Lee’s breakthrough research concerns the development of biodegradable, polyoxalate nanoparticles. This material specifically targets inflammatory areas and releases anti-inflammatory and antioxidant p-Hydroxybenzyl alcohol(HBA) to treat the infected areas. These nanoparticles can also be injected with fluorescent material to be used as labeling reagents for diagnostic medical imaging. Prof. Lee anticipates the possibilities of countless medical applications to emerge as the technology develops.


Until now, targeted drug delivery methods proved to be problematic because of difficulties controlling the release speed of the drugs and the consequential infection resulting from toxic non-biodegradable materials. There were also limitations filming and scanning these materials but Prof. Lee’s invention overcomes all of these obstacles. Since the new biodegradable polyoxalate nanoparticles can treat a targeted area, increase the effectiveness of the drug and reduce side effects, this new discovery is expected to field interest from pharmaceutical firms from all over the world and will act as a springboard for further development in the pharmacy field.


  1. Reduction of oxidative stress by p-hydroxybenzyl alcohol-containingbiodegradable polyoxalate nanoparticulate antioxidant(BIOMATERIALS)
  2. Enhanced cytosolic drug delivery using fully biodegradable poly(amino oxalate) particles(JOURNAL OF CONTROLLED RELEASE)
  3. Application of nano medicine in cardiovascular diseases and stroke(CURRENT PHARMACEUTICAL DESIGN)
  4. Antioxidant and anti-inflammatory activities of hydroxybenzyl alcohol releasing biodegradable polyoxalate nanoparticles(BIOMACROMOLECULES)
  5. Polyoxalate Nanoparticles as a Biodegradable and Biocompatible Drug Delivery Vehicle(BIOMACROMOLECULES)
  6. Physicobiological properties and biocompatibility of biodegradablepoly(oxalate-co-oxamide)(JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A)
  7. Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review.(RESPIRATORY RESEARCH)
  8. A Biodegradable and Biocompatible Drug Delivery System Based on Polyoxalate Microparticles(JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION)
  9. Synthesis and Characterization of High Molecular Weight Biodegradable Polyoxalate(POLYMER-KOREA)
  10. Microneedle-Mediated Transdermal Delivery of Chondroitin Sulfate(TISSUE ENGINEERING AND REGENERATIVE MEDICINE)


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